Searchable abstracts of presentations at key conferences on reproductive biology and medicine

ra0001p184 | (1) | WCRB2014

Derivation of naive-type induced pluripotent stem cells in cattle using piggyBac transposition of doxycycline-inducible transcription factors

Kawaguchi Takamasa , Tsukiyama Tomoyuki , Minami Naojiro , Yamada Masayasu , Matsuyama Shuichi , Kimura Koji , Imai Hiroshi

Pluripotent stem cells (PSCs) in large domestic animals including cattle are expected to be used as means for genetic improvement and production of disease-model animals. There are two types of PSCs: naive and primed. Ontogenetically, naive PSCs correspond to an earlier developmental state compared to other types of PSCs and have the capacity for producing chimeric offspring. Previously reported PSCs in large domestic animals are classified as primed type. In this study, putat...